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KMID : 0861019990140010037
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Korea Journal of Herbology
1999 Volume.14 No. 1 p.37 ~ p.44
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The Effect of Several Herbal Drugs on the Leukemia Cells
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崔湖榮/Choi, Ho-Young
金澤/柳志昌/卞德市/盧昇鉉/Kim, Tack/You, Ji-Chang/Byun, Duck-Si/Noh, Seung-Hyun
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Abstract
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I am reporting here a syntematic in vitro examination for specificity of anti-cancer effect of several oriental herbs, which have been used frequently for cancer pateints(therapy), on Molt-4 LCL(Lymphoblastoid Cell Line) Leukemic cells in relation to its density and time of incubation.
1. ErOH extract of Jujubae Fructus reduced Molt-4 cell´s survival rate effectively after 48 hours´ treatment at 1000㎍/㎖´s density and it reduced survival rate of LCL effectively after 12 hours´ treatment at 1000㎍/㎖´s density.
2. EtOH extract of Cordyceps reduced LCL´s survival rate effectively after 36 hour´s treatment at 1000㎍/㎖´s density.
2. EtOH extract of Fici Fructus reduced LCL´s survival rate effectively after 36 hours´ treatment at 1000㎍/㎖´s density.
4. EtOH extract of Trionycis reduced Molt-4 cell´s survival rate even at 500㎍/㎖ density and further effective at 1000㎍/㎖ density after 24 hours treatment and it killed the cells completely at 1000㎍/㎖ density after 48 hours treatment, It also Killed LCL completely after 12 hours and 36 hours´ treatment at 1000㎍/㎖´s density.
5. EtOH extract of Biotae Cacumen reduced LCL´s survival rate effectively after 12 hours´ treatment at 1000㎍/㎖´s density, and after 36 hours treatment it reduced LCL´s survival time very effectively.
6. EtOH extract of Psoraleae Fructus reduced Molt-4 cell´s survival rate very effectively after 24 hours´ treatment at 500㎍/㎖ and 1000㎍/㎖´s density, and after 48 hours´ treatment at 250㎍/㎖´s density it reduced effectively and it killed the cell completely at 500㎍/㎖ and 1000㎍/㎖´s density. It also killed LCL completely after 12 hours and 36 hours´ treatment at 1000㎍/㎖´s density.
I hope to proceed with more advanced experiment in vivo and clinically as for the two kinds of oriental herbs and another herbs effective for leukemia.
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